منابع مشابه
Data management strategies for multinational large-scale systems biology projects
Good accessibility of publicly funded research data is essential to secure an open scientific system and eventually becomes mandatory [Wellcome Trust will Penalise Scientists Who Don't Embrace Open Access. The Guardian 2012]. By the use of high-throughput methods in many research areas from physics to systems biology, large data collections are increasingly important as raw material for researc...
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Thinking big comes naturally to many biologists. Pursuing biological research on a monumental scale traditionally has not. Given the depth of that dichotomy, it is amazing that any established scientist would consider signing on to a biological research endeavor of the magnitude of the Human Genome Project (HGP), let alone agree to help steer the ship. Yet, each of us did. Now that biology’s fi...
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We plan to develop a systematic framework for assembling largescale computational biological models by reusing and combining already existing modelling efforts. Our goal is to build a software platform that will compile large-scale biomodels through successive integrations of smaller modules. The modules can be arbitrary executable programs accompanied by a set of (I/O) interface variables; the...
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Large-scale molecular biology technologies such as DNA microarrays and large-scale in situ hybridization (ISH) are used to gain an appreciation of global attributes in biological tissues and cells. Although many of these efforts use cDNA probes, an approach that makes use of designed oligo probes should offer improved consistency at uniform hybridization conditions and improved specificity, as ...
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Modelling and simulation form an integral part of a predictive and explanatory approach to computational systems biology. However, systems biology simulations are extremely challenging in requiring the modelling of many complex phenomena at multiple spatial and temporal scales. No single simulation can cover all the cases of interest. As a result, simulations must be developed “on demand” to su...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2006
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.106.180980